StackGuide
← All goals

Lose fat

Fat loss is energy balance, full stop, and every 'fat-burner' supplement is a distraction from that. Build a modest deficit you can sustain, keep protein and resistance training high to hold onto muscle, and use fiber and caffeine as honest, marginal helpers. GLP-1 medications are the real exception — genuinely powerful for the right person, and a clinician conversation, not a shortcut.

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Start here

The backbone. These do the real work — get them right before anything else.
01

Nutrition

B Moderate

Eat mostly minimally-processed food, get enough protein and fiber, and let total energy intake match whether you want to lose, hold, or gain. The specific named diet matters far less than sticking to a decent pattern — adherence beats ideology, every time.

In this stackA modest, sustainable energy deficit built from a pattern you don't hate. This is the whole mechanism.

Read the full guide on Nutrition →
02

Protein

B Moderate

The RDA of 0.8 g/kg prevents deficiency, not the same as optimal. If you resistance-train, benefits from added protein plateau around 1.6 g/kg per day. Hit a reasonable target across a few meals and stop optimizing the decimal places.

In this stackKeep it high (~1.6 g/kg or more) to preserve muscle in a deficit.

Read the full guide on Protein →
03

Strength

A Strong

Two sessions a week covering the major movement patterns is enough to bend the curve. Muscle-strengthening activity tracks with 10–17% lower mortality, and the dose-response peaks early — around 30–60 minutes a week — so you do not need to live in the gym.

In this stackNon-negotiable in a cut — it signals the body to keep muscle instead of burning it.

Read the full guide on Strength →
04

Aerobic base

A Strong

Accumulate easy aerobic minutes most weeks — conversational-pace Zone 2 — and add one or two harder sessions once the base is there. Going from low to even moderate fitness is the biggest mortality dividend in this entire guide, and it's mostly boring, repeatable volume.

In this stackAdds to the deficit and improves fitness; walking counts.

Read the full guide on Aerobic base →

Worth adding

Real, evidence-backed help on top of the base.
05

Psyllium

B Moderate

Psyllium is a well-studied, cheap gel-forming fiber. Around 10 g/day meaningfully lowers LDL, modestly improves glycemic control, and reliably normalizes bowel habits in both directions. Ramp up slowly to avoid bloating and always take it with a full glass of water.

In this stack5–10 g before meals for satiety and steadier glucose.

Read the full guide on Psyllium →
06

Caffeine

A Strong

Caffeine reliably improves endurance, power, and alertness — it's the most evidence-backed legal ergogenic aid there is. Up to ~400 mg/day is safe for most healthy adults. The catch is timing: with a ~5-hour half-life, caffeine taken even 6 hours before bed measurably degrades sleep. Treat it as the drug it is — powerful, useful, and easy to mistime.

In this stackModest appetite and output effect; not a fat-burner in any meaningful sense.

Read the full guide on Caffeine →

Situational

Low-stakes extras — only if they fit your case.
07

Berberine

C Suggestive

Berberine modestly lowers fasting glucose, HbA1c, and LDL in trials — real effects, but small, and it is emphatically not a GLP-1 drug. It causes frequent GI upset, meaningfully inhibits CYP450 drug metabolism, and is contraindicated in pregnancy. Worth a clinician conversation, not a casual TikTok purchase.

In this stack'Nature's Ozempic' is marketing. Modest glucose/lipid effects; it is not a GLP-1.

Read the full guide on Berberine →

Understand first

Powerful or over-hyped. Read the full guide and talk to a clinician before acting.
08

GLP-1 (semaglutide)

A Strong

For the right person, semaglutide produces weight loss and cardiovascular-risk reduction that lifestyle alone rarely matches — about 15% body weight in one trial, and 20% fewer cardiovascular events in another. It's a prescription with real GI side effects, ongoing cost, and unsettled questions about lifelong use. This is a clinician conversation, full stop.

In this stackFor obesity or real cardiometabolic risk, under a clinician — powerful, with real side effects and cost. Pair with protein and lifting to protect muscle.

Read the full guide on GLP-1 (semaglutide) →